Symbol Name ID |
Gfi1
growth factor independent 1 transcription repressor MGI:103170 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Neutropenia |
B lymphocytopenia |
Monocytosis |
Acute myeloid leukemia |
Disease(s) Associated with GFI1 | ||||
acute myeloid leukemia | ||||
severe congenital neutropenia 2 |
Mouse Phenotypes | hematopoietic system phenotype |
abnormal granulocyte differentiation |
abnormal monocyte differentiation |
abnormal T cell proliferation |
decreased NK cell degranulation |
small thymus |
thymus hypoplasia |
decreased thymocyte number |
abnormal definitive hematopoiesis |
abnormal lymphopoiesis |
abnormal NK cell differentiation |
abnormal T cell differentiation |
decreased double-negative T cell number |
arrested T cell differentiation |
abnormal myelopoiesis |
decreased neutrophil cell number |
absent neutrophils |
decreased granulocyte number |
abnormal neutrophil morphology |
decreased B cell number |
abnormal T cell subpopulation ratio |
decreased T cell number |
decreased lymphocyte cell number |
increased monocyte cell number |
increased hematopoietic stem cell number |
abnormal monocyte morphology |
abnormal NK cell physiology |
abnormal T-helper 2 physiology |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||
Gfi1tm1.1Wep/Gfi1tm1.1Wep | |||||||||||||||||||||||||||||
Gfi1tm1Tmo/Gfi1tm1Tmo | |||||||||||||||||||||||||||||
Gfi1tm1Wep/Gfi1tm1Wep | |||||||||||||||||||||||||||||
Gfi1tm2Tmo/Gfi1tm2Tmo | |||||||||||||||||||||||||||||
Gfi1tm3(Gfib1)Tmo/Gfi1tm3(Gfib1)Tmo | * | ||||||||||||||||||||||||||||
Gfi1tm4Tmo/Gfi1tm4Tmo | |||||||||||||||||||||||||||||
Gfi1tm6.1(GFI1)Tmo/Gfi1tm6.1(GFI1)Tmo | * | ||||||||||||||||||||||||||||
Gfi1Gen/Gfi1+ | |||||||||||||||||||||||||||||
Gfi1tm1Wep/Gfi1tm1Wep Tg(Cd4-cre)1Cwi/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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